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吗叮啉不“合群”的胃药在众多用于治疗胃病的药物中,吗叮啉属于后起之秀。吗叮啉是目前临床上应用较多的新型胃肠动力药,主要用于反流性食管炎、反流性胃炎和慢性胃炎、食管炎引起的消化不良症状,也可用于各种原因引起的恶心、呕吐。吗叮啉系外周性多巴胺受体拮抗剂,可促进胃肠道的蠕动和张力恢复,促进胃排空。由于其作用原理与其他胃药不同,因此,一般不能合用,如合用,或者互相减弱药效,或者增强不良反应。 抗酸剂:抗酸剂都是弱碱性化合物,能中和胃酸,从而解除胃酸对胃及十二指肠黏膜的刺激,修复溃疡面。抗酸剂的效力受胃排空速度的影响较大,胃排空速度慢,此类药物在胃内停留时间就长,易分散在胃黏膜表面,保护黏膜的作用就充分。吗叮啉由于增加胃肠蠕动,加速胃的排空,二者合用将缩短抗酸剂在胃内的停留时间,使其疗效降低。 硫糖铝:硫糖铝是蔗糖酯的碱性铝盐,用于治疗胃和十二指肠溃疡。此药在胃内能与胃蛋白酶络合,形成复合物,抑制其分解蛋白质,并与胃黏膜的黏蛋白络合形成保护膜,覆盖溃疡面,有利于黏膜再生和溃疡愈合。同时,此药有抗酸作用。如将硫糖铝与吗叮啉配伍,其作用必然会由于吗叮啉的胃动力作用而减弱。 胃蛋白
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